4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
aatbio(优势品牌)
主营:主营:研究并生产荧光和发光探针,信号转导研究的试剂
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Other_biological_dyes > AAT Bioquest/Zinquin AM*超纯级*/21261/1毫克
商品详细AAT Bioquest/Zinquin AM*超纯级*/21261/1毫克
AAT Bioquest/Zinquin AM*超纯级*/21261/1毫克
AAT Bioquest/Zinquin AM*超纯级*/21261/1毫克
商品编号: 21261
品牌: aatbio
市场价: ¥56560.00
美元价: 33936.00
产地: 美国(厂家直采)
公司:
产品分类: 其他生物染料
公司分类: Other_biological_dyes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Overview
PrinterFriendlyVersion

Ex/Em(nm)344/385
MW458.48
CAS#N/A
SolventDMSO
StorageF/D/L
CategorySmallMoleculeDetection
MetalIons
RelatedpHandIonIndicators
BiochemicalAssays
ZinquinAMesterisalipophilic,zinc-sensitive,cell-permeablefluorescentprobe.ItisretainedinlivingcellsbecausetheAMesteriscleavedbycytosolicesterasetogiveZinquinthatcarryanegativecharge,preventingitseffluxacrosstheplasmamembrane.Zinquinfluorescentprobesmaybeloadedintocellsbyintheculturemediumcontaining5-40?MZinquinethylesterinPBSwithcalciumandmagnesium(orinculturemedium).CellsarenormallyincubatedwiththeZinquinethylesterfor15-30minutesat37°C.ExactloADIngconcentration,timeandtemperaturedependonthepurposeoftheexperimentandcelltype,andsowillneedtobeoptimizedexperimentally.CellsarewashedinPBSwithculturemediumtoremoveextracellularremainingdye.Cellsareobservedundermicroscopeorusedforconfocalmicroscopy,FACSorspectrofluorimetryanalysis.Zincisthesecondmostabundanttransitionmetalinthebodyanditisessentialascatalytic,structuralandregulatoryion.Zincionsareinvolvedinhomeostasis,immuneresponses,oxidativestress,apoptosisandaging.Zinchasbeenproposedtofunctionasaconventionalneurotransmitterforthepresynapticneuronandasatransmembranesignaltotraversethepostsynapticneuron.AberrantzincmetabolismisassociatedwithmanyneurologicaldiseasesincludingAlzheimer"sdisease,Parkinson"sdiseaseandepilepsy.Themostsuitabletechniqueforinvivomonitoringofzinchasbeenproventobefluorescenceimaging.
References&Citations
PrinterFriendlyVersion

1.   ColvinRA,LaskowskiM,FontaineCP.(2006)Zinquinidentifiessubcellularcompartmentalizationofzincincorticalneurons.Relationtothetraffickingofzincandthemitochondrialcompartment.BrainRes,1085,1.

2.   JansenS,ArningJ,DulcksT,BeyersmannD.(2004)S-NitrosocompoundsinterferewithzincprobingbyZinquin.AnalBiochem,332,145.

3.   HendricksonKM,GeueJP,WynessO,LincolnSF,WardAD.(2003)CoordinationandfluorescenceoftheintracellularZn2+probe[2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]aceticacid(ZinquinA)internaryZn2+complexes.JAmChemSoc,125,3889.

4.   SnitsarevV,BuddeT,StrickerTP,CoxJM,KrupaDJ,GengL,KayAR.(2001)FluorescentdetectionofZn(2+)-richvesicleswithZinquin:mechanismofactioninlipidenvironments.BiophysJ,80,1538.

5.   KimberMC,MahadevanIB,LincolnSF,WardAD,TiekinkER.(2000)Thesynthesisandfluorescentpropertiesofanaloguesofthezinc(II)specificfluorophorezinquinester.JOrgChem,65,8204.

6.   ZalewskiPD,JianX,SoonLL,BreedWG,SeamarkRF,LincolnSF,WardAD,SunFZ.(1996)ChangesindistributionoflABIlezincinmousespermatozoaduringmaturationintheepididymisassessedbythefluorophoreZinquin.ReprodFertilDev,8,1097.

7.   ZalewskiPD,ForbesIJ,SeamarkRF,BorlinghausR,BettsWH,LincolnSF,WardAD.(1994)Fluxofintracellularlabilezincduringapoptosis(gene-directedcelldeath)revealedbyaspecificchemicalprobe,Zinquin.ChemBiol,1,153.

8.   CoyleP,ZalewskiPD,PhilcoxJC,ForbesIJ,WardAD,LincolnSF,MahadevanI,RofeAM.(1994)Measurementofzincinhepatocytesbyusingafluorescentprobe,zinquin:relationshiptometallothioneinandintracellularzinc.BiochemJ,303(Pt3),781.


ViewAllAsPDF
品牌介绍
美国AAT Bioquest Inc.(前身是ABD Bioquest,Inc.)是一家为从事生命科学研究、诊断研发及药物开发的科学家研发、生产和销售生物分析研究试剂和试剂盒的公司。公司致力于光谱学检测领域,包括吸收(颜色)、荧光和发光技术。AAT Bioquest的产品帮助全世界的科学家和生物医药研究者更好的了解生物化学、免疫学、细胞生物学和分子生物学等领域。AAT Bioquest会不断研发新产品,快速地丰富各个领域的产品。 1)提供反应探针和发光探针,生物素和端粒酶能够应用于标记药物小分子和生物聚合物,如蛋白、核酸以及其他碳水化合物; 2)研究并生产荧光和发光探针用于检测蛋白,核酸和活细胞; 3)不断推出新型的荧光和发光探针用于检测多种酶,特别是检测水解酶和氧化还原酶类; 4)致力于开发用于信号转导研究的试剂; 5)提供生理和神经探针,特别是钙离子指示剂和膜电位探针。
品牌分类
淋巴细胞信号传导 GPCR抗体 羰基活性生物素 细胞代谢 胺反应生物素 链霉亲和素结合物 生物素化抗IgGs 乙酰基特异性抗体 细胞骨架抗体
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616