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主营:主营:研究并生产荧光和发光探针,信号转导研究的试剂
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当前位置: 首页 > 产品中心 > Other_biological_dyes > AAT Bioquest/PG-cholesterylamine/36700/1 mg
商品详细AAT Bioquest/PG-cholesterylamine/36700/1 mg
AAT Bioquest/PG-cholesterylamine/36700/1 mg
AAT Bioquest/PG-cholesterylamine/36700/1 mg
商品编号: 36700
品牌: aatbio
市场价: ¥143560.00
美元价: 86136.00
产地: 美国(厂家直采)
公司:
产品分类: 其他生物染料
公司分类: Other_biological_dyes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Overview
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Ex/Em(nm)492/519
MW1043.73
CAS#1264272-41-4
SolventDMSO
StorageF/D/L
CategoryTransporters
BileAcidTransporters
RelatedCellFunctionalAnalysis
PG-cholesterylaminewasreportedbyZhangetal.tobeanexcellentfluorescentprobeformonitoringcholesterolefflux.Reversecholesteroltransportistheprocessbywhichextrahepaticcells,includingmacrophage-derivedfoamcellsinarterialatheroscleroticplaque,transportexcessivecholesterolbacktotheliverforbileacidsynthesisandexcretion,thusloweringtheperipherallipidburden.PG-cholesterylamineisaderivativeofN-alkyl-3β-cholesterylaminelabeledwithafluoresceinderivative,PennsylvaniaGreen(PG).ComparedwiththetrADItionalradioisotope-basedassay,thisfluorescentprobegavesimilarresultsinthepresenceofknownmodulatorsofcholesterolefflux,suchascyclicAMP,anddifferentcholesterolacceptors.Whenthefluorescentprobewasemployedinahigh-throughputscreeningformat,avarietyofchemicalsandbioactivecompoundswithknownandunknowneffectsoncholesteroleffluxcouldbetestedsimultaneouslybyplate-readerinashortperiodoftime.TreatmentofTHP-1-derivedmacrophageswithinhibitorsofthemembranetransporterATP-bindingcassetteA1,suchasglyburideoraspecificantibody,significantlyreducedtheexportofthisfluorescentcompound,indicatingthatATP-bindingcassetteA1representstheprimarymediatorofitscellularefflux.PG-cholesterylamineprovidesasafe,sensitiveandreproducIBLealternativetoradioactiveassaysineffluxexperiments.
SpectrumAdvancedSpectrumViewer

Sorry,yourbrowserdoesnotsupportinlineSVG.RelativeIntensity(%)100806040200Sorry,yourbrowserdoesnotsupportinlineSVG.
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References&Citations
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1.   Qiu,C.;Zhao,X.;Zhou,Q.;Zhang,Z.,High-densitylipoproteincholesteroleffluxcapacityisinverselyassociatedwithcardiovascularrisk:asystematicreviewandmeta-analysis.LipidsHealthDis2017,16(1),212.

2.   Shen,W.J.;Azhar,S.;Kraemer,F.B.,SR-B1:AUniqueMultifunctionalReceptorforCholesterolInfluxandEfflux.AnnuRevPhysiol2017.

3.   Ronsein,G.E.;Vaisar,T.,Inflammation,remodeling,andotherfactorsaffectingHDLcholesterolefflux.CurrOpinLipidol2017,28(1),52-59.

4.   Sun,R.L.;Huang,C.X.;Bao,J.L.;Jiang,J.Y.;Zhang,B.;Zhou,S.X.;Cai,W.B.;Wang,H.;Wang,J.F.;Zhang,Y.L.,CC-ChemokineLigand2(CCL2)SuppressesHighDensityLipoprotein(HDL)InternalizationandCholesterolEffluxviaCC-ChemokineReceptor2(CCR2)Inductionandp42/44Mitogen-activatedProteinKinase(MAPK)ActivationinHumanEndothelialCells.JBiolChem2016,291(37),19532-44.

5.   Liang,Y.;Yang,X.;Ma,L.;Cai,X.;Wang,L.;Yang,C.;Li,G.;Zhang,M.;Sun,W.;Jiang,Y.,Homocysteine-mediatedcholesteroleffluxviaABCA1andACAT1DNAmethylationinTHP-1monocyte-derivedfoamcells.ActaBiochimBiophysSin(Shanghai)2013,45(3),220-8.

6.   Zhang,J.;Cai,S.;Peterson,B.R.;Kris-Etherton,P.M.;Heuvel,J.P.,Developmentofacell-based,high-throughputscreeningassayforcholesteroleffluxusingafluorescentmimicofcholesterol.AssayDrugDevTechnol2011,9(2),136-46.


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品牌介绍
美国AAT Bioquest Inc.(前身是ABD Bioquest,Inc.)是一家为从事生命科学研究、诊断研发及药物开发的科学家研发、生产和销售生物分析研究试剂和试剂盒的公司。公司致力于光谱学检测领域,包括吸收(颜色)、荧光和发光技术。AAT Bioquest的产品帮助全世界的科学家和生物医药研究者更好的了解生物化学、免疫学、细胞生物学和分子生物学等领域。AAT Bioquest会不断研发新产品,快速地丰富各个领域的产品。 1)提供反应探针和发光探针,生物素和端粒酶能够应用于标记药物小分子和生物聚合物,如蛋白、核酸以及其他碳水化合物; 2)研究并生产荧光和发光探针用于检测蛋白,核酸和活细胞; 3)不断推出新型的荧光和发光探针用于检测多种酶,特别是检测水解酶和氧化还原酶类; 4)致力于开发用于信号转导研究的试剂; 5)提供生理和神经探针,特别是钙离子指示剂和膜电位探针。
品牌分类
淋巴细胞信号传导 GPCR抗体 羰基活性生物素 细胞代谢 胺反应生物素 链霉亲和素结合物 生物素化抗IgGs 乙酰基特异性抗体 细胞骨架抗体
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