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主营:主营:研究并生产荧光和发光探针,信号转导研究的试剂
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当前位置: 首页 > 产品中心 > Fluorescent_dyes > AAT Bioquest/iFluor 750和贸易;RGD结合物/36800/1mg
商品详细AAT Bioquest/iFluor 750和贸易;RGD结合物/36800/1mg
AAT Bioquest/iFluor 750和贸易;RGD结合物/36800/1mg
AAT Bioquest/iFluor 750和贸易;RGD结合物/36800/1mg
商品编号: 36800
品牌: aatbio
市场价: ¥85560.00
美元价: 51336.00
产地: 美国(厂家直采)
公司:
产品分类: 荧光染料
公司分类: Fluorescent_dyes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Overview
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Ex/Em(nm)750/780
MW~1600
CAS#N/A
SolventDMSO
StorageF/D/L
CategoryGPCR
ReceptorBindingAssays
RelatedCellFunctionalAnalysis
BiochemicalAssays
Near-infraredfluorescenceopticalimaging(alsocalledinvivoImaging)isemergingasapowerfultechnologyforstudyingdiseasesatmolecularlevelinsmallanimalmodels.WaterandBIOLOGicaltissueshaveminimalabsorbanceandautofluorescenceintheNIRwindow(650-900nm),thusallowingefficientphotonpenetrationinto,andoutoftissuewithlowintra-tissuescattering.AcrossthisNIRwindow,lightabsorptionbyphysiologicallyabundantmoleculessuchashemoglobin,oxyhemoglobinanddeoxyhemoglobinisalsoreducedtoaminimum.InvivoimagingsystemswithbiocompatIBLefluorescenceagentsarebeingdevelopedandoptimizedforuseinthenearinfraredspectralregion-ensuringmaximumlightpenetrationandhighestsensitivity.Thecelladhesionmoleculeintegrinisinvolvedinangiogenesisandmetastasisinmanytumortypes.Integrinissignificantlyup-regulatedinactivatedendothelialcellsandfast-growingsolidtumorcells,comparedtoitsminimumexpressioninquiescentbloodvesselsandmostnormaltissues.iFluor™750-labeledmonomericarginine-glycine-asparticacid(RGD)peptidec(RGDyK)specificallytargetsintegrinbothincellcultureandinlivingsubjects.TheinvivoefficacyofiFluor™750-c(RGDyK)dependsonmanyfactors,includingthereceptoraffinity,specificity,molecularsize,overallmolecularcharge,hydrophilicityandmetabolicstABIlity.
SpectrumAdvancedSpectrumViewer

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References&Citations
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1.HuangY,LiuW,GaoF,FangX,ChenY.(2016)c(RGDyK)-decoratedPluronicmicellesforenhanceddoxorubicinandpaclitaxeldeliverytobrainglioma.IntJNanomedicine,11,1629.

2.PandyaDN,HantganR,BudzevichMM,KockND,MorseDL,BatistaI,MintzA,LiKC,WadasTJ.(2016)PreliminaryTherapyEvaluationof(225)Ac-DOTA-c(RGDyK)DemonstratesthatCerenkovRADIationDerivedfrom(225)AcDaughterDecayCanBeDetectedbyOpticalImagingforInVivoTumorVisualization.Theranostics,6,698.

3.JiT,GaoS,LiuZ,XingH,ZhaoG,MaQ.(2016)99mTc-Glu-c(RGDyK)-BombesinSPECTCanReduceUnnecessaryBiopsyofMassesThatAreBI-RADSCategory4onUltrasonography.JNuclMed,57,1196.

4.ChenY,ZhangW,HuangY,GaoF,FangX.(2016)InVivoBiodistributionandAnti-TumorEfficacyEvaluationofDoxorubicinandPaclitaxel-LoadedPluronicMicellesDecoratedwithc(RGDyK)Peptide.PLoSOne,11,e0149952.

5.ChenY,ZhangW,HuangY,GaoF,FangX.(2015)Dual-functionalc(RGDyK)-decoratedPluronicmicellesdesignedforantiangiogenesisandthetreatmentofdrug-resistanttumor.IntJNanomedicine,10,4863.

6.GaoY,ZhouY,ZhaoL,ZhangC,LiY,LiJ,LiX,LiuY.(2015)EnhancedantitumorefficacybycyclicRGDyK-conjugatedandpaclitaxel-loadedpH-responsivepolymericmicelles.ActaBiomater,23,127.

7.GuoL,DingW,ZhengLM.(2014)TheC(RgdyK)-conjugatedFe3O4nanoparticleswithhighdrugloadfordual-targetingintegrinalpha(v)beta3-expressingcancercells.JNanosciNanotechnol,14,4858.

8.OxboelJ,Brandt-LarsenM,Schjoeth-EskesenC,MyschetzkyR,El-AliHH,MadsenJ,KjaerA.(2014)ComparisonoftwonewangiogenesisPETtracers68Ga-NODAGA-E[c(RGDyK)]2and(64)Cu-NODAGA-E[c(RGDyK)]2;invivoimagingstudiesinhumanxenografttumors.NuclMedBiol,41,259.

9.KimJH,KimYH,KimYJ,YangBY,JeongJM,YounH,LeeDS,LeeJS.(2013)Quantitativepositronemissiontomographyimagingofangiogenesisinratswithforelimbischemiausing(68)Ga-NOTA-c(RGDyK).Angiogenesis,16,837.

10.Ocampo-GarciaBE,Santos-CuevasCL,DeLeon-RodriguezLM,Garcia-BecerraR,Ordaz-RosadoD,Luna-GuitierrezMA,Jimenez-MancillaNP,Romero-PinaME,Ferro-FloresG.(2013)Designandbiologicalevaluationof(9)(9)mTc-N(2)S(2)-Tat(49-57)-c(RGDyK):ahybrid


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品牌介绍
美国AAT Bioquest Inc.(前身是ABD Bioquest,Inc.)是一家为从事生命科学研究、诊断研发及药物开发的科学家研发、生产和销售生物分析研究试剂和试剂盒的公司。公司致力于光谱学检测领域,包括吸收(颜色)、荧光和发光技术。AAT Bioquest的产品帮助全世界的科学家和生物医药研究者更好的了解生物化学、免疫学、细胞生物学和分子生物学等领域。AAT Bioquest会不断研发新产品,快速地丰富各个领域的产品。 1)提供反应探针和发光探针,生物素和端粒酶能够应用于标记药物小分子和生物聚合物,如蛋白、核酸以及其他碳水化合物; 2)研究并生产荧光和发光探针用于检测蛋白,核酸和活细胞; 3)不断推出新型的荧光和发光探针用于检测多种酶,特别是检测水解酶和氧化还原酶类; 4)致力于开发用于信号转导研究的试剂; 5)提供生理和神经探针,特别是钙离子指示剂和膜电位探针。
品牌分类
淋巴细胞信号传导 GPCR抗体 羰基活性生物素 细胞代谢 胺反应生物素 链霉亲和素结合物 生物素化抗IgGs 乙酰基特异性抗体 细胞骨架抗体
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