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主营:主营:研究并生产荧光和发光探针,信号转导研究的试剂
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当前位置: 首页 > 产品中心 > Other_biological_dyes > AAT Bioquest/ADP-TAMRA结合物[5-TAMRA-eda-ADP]/13606/100 nmol
商品详细AAT Bioquest/ADP-TAMRA结合物[5-TAMRA-eda-ADP]/13606/100 nmol
AAT Bioquest/ADP-TAMRA结合物[5-TAMRA-eda-ADP]/13606/100 nmol
AAT Bioquest/ADP-TAMRA结合物[5-TAMRA-eda-ADP]/13606/100 nmol
商品编号: 13606
品牌: aatbio
市场价: ¥143560.00
美元价: 86136.00
产地: 美国(厂家直采)
公司:
产品分类: 其他生物染料
公司分类: Other_biological_dyes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Overview
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Ex/Em(nm)544/575
MW1309.30
CAS#N/A
SolventDMSO
StorageF/D/L
CategoryEnzymeDetection
Phosphodiesterases
Related
FluorescentlylabeledADPmoleculesareusedtoscreeningADP-bindingenzymesandotherproteintargetsfordrugdiscovery.ThisADP-TAMRAhasbeentestedforbindingkynureninemonooxygenase(KMO)withaK(d)valueof0.60±0.05?MandtotheNMOsfromAspergillusfumigatusandMycobacteriumsmegmatiswithK(d)valuesof2.1±0.2and4.0±0.2?M,respectively(AnalBiochem.2012,425,80-7).TheassaywastestedincompetitivebindingexperimentswithsubstratesandproductsofKMOandanNMO.NMOsareessentialforpathogenesisinfungiandbacteria.NMOscatalyzethehydroxylationofsineandornithineinthebiosynthesisofhydroxamate-containingsiderophores.InhibitionofKMO,whichcatalyzestheconversionofkynurenineto3-hydroxykynurenine,alleviatesneurodegenerativedisorderssuchasHuntington"sandAlzheimer"sdiseasesandbraininfectionscausedbytheparasiteTrypanosomabrucei.
SpectrumAdvancedSpectrumViewer

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References&Citations
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  1. LinCY,HuangJY,LoLW.(2013)Decipheringthecatalysis-associatedconformationalchangesofhumanadenylatekinase1withsingle-moleculespectroscopy.JPhysChemB,117,13947.
  2. SzymanskiMR,JezewskaMJ,BujalowskiW.(2010)TheEscherichiacoliPriAhelicase-double-strandedDNAcomplex:locationofthestrongDNA-bindingsubsiteonthehelicasedomainoftheproteinandtheaffinitycontrolbythetwonucleotide-bindingsitesoftheenzyme.JMolBiol,402,344.
  3. HunkeC,TadwalVS,ManimekalaiMS,RoessleM,GruberG.(2010)TheeffectofNBD-Clinnucleotide-bindingofthemajorsubunitalphaandBofthemotorproteinsF1FOATPsynthaseandA1AOATPsynthase.JBioenergBiomembr,42,1.
  4. RamalingamJK,HunkeC,GaoX,GruberG,PreiserPR.(2008)ATP/ADPbindingtoanovelnucleotidebindingdomainofthereticulocyte-bindingproteinPy235ofPlasmodiumyoelii.JBiolChem,283,36386.
  5. SenB,ChakrabortyA,DattaR,BhattacharyyaD,DattaAK.(2006)ReversalofADP-mediatedaggregationofadenosinekinasebycyclophilinleadstoitsreactivation.Biochemistry,45,263.
  6. CochranJC,GilbertSP.(2005)ATPasemechanismofEg5intheabsenceofmicrotubules:insightintomicrotubuleactivationandallostericinhibitionbymonastrol.Biochemistry,44,16633.
  7. GuoQ,ChenB,WangX.(2004)EvidenceforproximalcysteineandlysineresiduesatorneartheactivesiteofargininekinaseofStichopusjaponicus.Biochemistry(Mosc),69,1336.
  8. VieyraA,MintzE,LoweJ,GuillainF.(2004)Ca2+bindingtosarcoplasmicreticulumATPasephosphorylatedbyPirevealsfourthapsigargin-sensitiveCa2+sitesinthepresenceofADP.BiochimBiophysActa,1667,103.
  9. WangQ,SongC,YangX,LiCC.(2003)D1ringisstableandnucleotide-independent,whereasD2ringundergoesmajorconformationalchangesduringtheATPasecycleofp97-VCP.JBiolChem,278,32784.
  10. FlowersS,BiswasEE,BiswasSB.(2003)ConformationaldynamicsofDnaBhelicaseuponDNAandnucleotidebinding:analysisbyintrinsictryptophanfluorescencequenching.Biochemistry,42,1910.

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品牌介绍
美国AAT Bioquest Inc.(前身是ABD Bioquest,Inc.)是一家为从事生命科学研究、诊断研发及药物开发的科学家研发、生产和销售生物分析研究试剂和试剂盒的公司。公司致力于光谱学检测领域,包括吸收(颜色)、荧光和发光技术。AAT Bioquest的产品帮助全世界的科学家和生物医药研究者更好的了解生物化学、免疫学、细胞生物学和分子生物学等领域。AAT Bioquest会不断研发新产品,快速地丰富各个领域的产品。 1)提供反应探针和发光探针,生物素和端粒酶能够应用于标记药物小分子和生物聚合物,如蛋白、核酸以及其他碳水化合物; 2)研究并生产荧光和发光探针用于检测蛋白,核酸和活细胞; 3)不断推出新型的荧光和发光探针用于检测多种酶,特别是检测水解酶和氧化还原酶类; 4)致力于开发用于信号转导研究的试剂; 5)提供生理和神经探针,特别是钙离子指示剂和膜电位探针。
品牌分类
淋巴细胞信号传导 GPCR抗体 羰基活性生物素 细胞代谢 胺反应生物素 链霉亲和素结合物 生物素化抗IgGs 乙酰基特异性抗体 细胞骨架抗体
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